Last update
4/3/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 1 Research
5
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
5
We explored the effectiveness of folate treatment in children with ear infections by evaluating hematologic abnormalities during antibiotic therapy. In a study involving 120 children with otitis media, we divided the participants into three groups: one received cotrimoxazole (the combination of trimethoprim and sulfamethoxazole), the second group received cotrimoxazole with folinic acid (a form of folate), and the third group was given amoxicillin.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
Read More
Most Useful Reviews
7.5
Gradual improvement
I consistently take B12 as prescribed at the hospital for my ear problems. I feel my condition is improving gradually with daily intake.
Read More
7.5
Effective ingredients
The quality of the B12 supplements is excellent, and I felt the effects early on. The larger packaging is convenient and adds to my satisfaction.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 1 Research
5
- All Researches
5
We explored the effectiveness of folate treatment in children with ear infections by evaluating hematologic abnormalities during antibiotic therapy. In a study involving 120 children with otitis media, we divided the participants into three groups: one received cotrimoxazole (the combination of trimethoprim and sulfamethoxazole), the second group received cotrimoxazole with folinic acid (a form of folate), and the third group was given amoxicillin.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Gradual improvement
I consistently take B12 as prescribed at the hospital for my ear problems. I feel my condition is improving gradually with daily intake.
Read More
7.5
Effective ingredients
The quality of the B12 supplements is excellent, and I felt the effects early on. The larger packaging is convenient and adds to my satisfaction.
Read More
Frequently Asked Questions
7.5
Gradual improvement
I consistently take B12 as prescribed at the hospital for my ear problems. I feel my condition is improving gradually with daily intake.
7.5
Effective ingredients
The quality of the B12 supplements is excellent, and I felt the effects early on. The larger packaging is convenient and adds to my satisfaction.
5
We explored the effectiveness of folate treatment in children with ear infections by evaluating hematologic abnormalities during antibiotic therapy. In a study involving 120 children with otitis media, we divided the participants into three groups: one received cotrimoxazole (the combination of trimethoprim and sulfamethoxazole), the second group received cotrimoxazole with folinic acid (a form of folate), and the third group was given amoxicillin.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
We observed that 35% of children receiving cotrimoxazole alone developed neutropenia (a low level of neutrophils, which are essential for fighting infections), while only 17.5% in the cotrimoxazole plus folinic acid group experienced this issue. Early neutropenia was consistent among all groups and usually resolved on its own. However, late neutropenia, occurring after ten days, was specific to those treated with cotrimoxazole alone.
Importantly, the study indicated that the late neutropenia connected to cotrimoxazole use could be linked to a blockage in folinic acid metabolism. This suggests that adding folinic acid may help prevent this side effect. However, it’s worth noting that while folate treatment appears beneficial in reducing the risk of late neutropenia, the study did not isolate folate as a singular treatment for ear infections themselves.
References
- Principi N, Marchisio P, Biasini A, Dalla Villa A, Biasini G. Early and late neutropenia in children treated with cotrimoxazole (trimethoprim-sulfamethoxazole). Acta Paediatr Scand. 1984;73:763. PubMed
